Natural GLP-1 lasts ~2 minutes
Every time you eat, your gut releases a hormone called GLP-1 that signals fullness, triggers insulin release, and slows digestion. An enzyme called DPP-4 destroys it within 1 to 2 minutes.
Support longevity
Tirzepatide
Tirzepatide / Glycine / B12
$149.00/mo
Activates both GLP-1 and GIP receptors. Lower doses can reduce side effects while preserving some of the key metabolic benefits.
Licensed in all 50 states
No insurance required
Licensed US pharmacies
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- Unlimited follow-up with licensed physicians
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There has been growing scientific data suggesting that GLP-1 agonists are beneficial for longevity via several mechanisms that are independent from weight loss.
Third Avenue Clinical Team
Board-certified physicians & researchers
Why GLP-1s
Natural hormone breaks down in minutes. GLP-1s last days.
Engineered to last longer
GLP-1 receptor agonists are lab-engineered versions of this hormone, modified to resist DPP-4 breakdown and stay active long enough to sustain appetite control and blood sugar regulation.
See source
Source: Nauck & Meier, European Journal of Endocrinology (2019); Gentilella et al., Diabetes/Metabolism Research and Reviews (2019)Sustained effects: minutes to days
The result: half-lives ranging from 2.5 hours to approximately 7 days — up to 5,000 times longer than the natural hormone.
See source
Source: Nauck & Meier, European Journal of Endocrinology (2019); Gentilella et al., Diabetes/Metabolism Research and Reviews (2019)Charts and references are illustrative representations intended to communicate published research findings and the known pharmacologic properties of a medication class. They do not establish that any specific formulation or treatment program will produce identical results. Compounded medications are not evaluated by the FDA for safety, quality or efficacy.
How GLP-1 RA works
Tirzepatide activates both GLP-1 and GIP receptors.
Tirzepatide is a dual GLP-1 and GIP receptor agonist that mimics two gut hormones. Receptors are located in the brain, gut, heart, and pancreas, where activation supports appetite regulation, blood sugar balance, and metabolic function.
Activates GLP-1 and GIP receptors
Your gut releases two metabolic hormones after eating: GLP-1 and GIP. Both regulate blood sugar, appetite, and energy use, but they break down in minutes. Tirzepatide activates both pathways and lasts roughly 5 days.
Preserves benefits
Research suggests that low-dose tirzepatide can activate longevity-relevant pathways including moderate weight loss, glycemic control, and anti-inflammatory effects.
Can reduce side effects
Tirzepatide side effects may scale with dose. In clinical trials, cutting the dose from 15 mg to 5 mg reduced nausea by one-third.
How Third Avenue works
From intake to your door in three to seven days
Step 1
Medical intake
Answer a guided set of questions covering your medical history, current medications, goals, and treatment preferences.
A few minutesStep 2
Doctor review
A U.S.-licensed, board-certified physician reviews your intake and recommends a medication, if appropriate.
Within 72 hoursStep 3
Fast shipping
Approved medications ship directly to your door in discreet packaging.
2-5 business daysStep 4
Unlimited messaging
Your doctor is available via chat any time for additional support. Video consults available.
Up to 12 months*Some states may require a synchronous audio and/or video consultation prior to a prescription being approved.
Why Third Avenue
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Proactive, doctor-led care
Treatment plans designed around your goals. No wait lists.
Transparent pricing
No membership fees, no hidden costs. Pay only after a doctor prescribes.
Board-certified doctors
Specialist physicians licensed in your state, with unlimited messaging.
Curated by longevity experts
Every protocol is built by medical experts based on longevity research.
Personalized dosing
Titration matched to your goals and tolerance.
What is Tirzepatide Microdose?
Tirzepatide activates longevity pathways tied to weight loss, glycemic control, and reduced inflammation by engaging both GLP-1 and GIP — the gut hormone signals that regulate appetite, blood sugar, and how the body stores and uses energy. Early research suggests these pathways may retain healthspan benefits even at lower doses, opening the door to personalized protocols that preserve the metabolic effects while often reducing side-effect burden.
How do you take Tirzepatide Microdose?
Tirzepatide Microdose is available in a weekly injectable form. Your provider will determine which medication and dose is appropriate for you. Always follow instructions from your doctor.
What are the side effects of Tirzepatide Microdose?
Higher doses of tirzepatide are associated with more side effects. At full dose, the most common side effects are nausea, vomiting, diarrhea, constipation, abdominal discomfort, and decreased appetite. Lower doses and slower titration can reduce the frequency of these side effects. Your provider will discuss side effects with you, along with dosing instructions.
Who shouldn't take Tirzepatide Microdose?
Not recommended for people with a personal or family history of medullary thyroid cancer or MEN2. Your doctor will evaluate whether Tirzepatide Microdose is appropriate for you.