Natural GLP-1 lasts ~2 minutes
Every time you eat, your gut releases a hormone called GLP-1 that signals fullness, triggers insulin release, and slows digestion. An enzyme called DPP-4 destroys it within 1 to 2 minutes.
Support longevity
Semaglutide
Semaglutide / Glycine / B12
$99.00/mo
Microdosing semaglutide activates the GLP-1 pathway at lower doses, reducing side effects and may support longevity protocols.
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Licensed US pharmacies
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There has been growing scientific data suggesting that GLP-1 agonists are beneficial for longevity via several mechanisms that are independent from weight loss.
Third Avenue Clinical Team
Board-certified physicians & researchers
Why GLP-1s
Natural hormone breaks down in minutes. GLP-1s last days.
Engineered to last longer
GLP-1 receptor agonists are lab-engineered versions of this hormone, modified to resist DPP-4 breakdown and stay active long enough to sustain appetite control and blood sugar regulation.
See source
Source: Nauck & Meier, European Journal of Endocrinology (2019); Gentilella et al., Diabetes/Metabolism Research and Reviews (2019)Sustained effects: minutes to days
The result: half-lives ranging from 2.5 hours to approximately 7 days — up to 5,000 times longer than the natural hormone.
See source
Source: Nauck & Meier, European Journal of Endocrinology (2019); Gentilella et al., Diabetes/Metabolism Research and Reviews (2019)Charts and references are illustrative representations intended to communicate published research findings and the known pharmacologic properties of a medication class. They do not establish that any specific formulation or treatment program will produce identical results. Compounded medications are not evaluated by the FDA for safety, quality or efficacy.
How GLP-1 RA works
Semaglutide activates GLP-1 receptors throughout the body.
Semaglutide is a GLP-1 receptor agonist that mimics the GLP-1 hormone produced in the gut. Receptors are located in the brain, gut, heart, and pancreas, where activation supports appetite regulation, blood sugar balance, and metabolic function.
Activates GLP-1 receptors
GLP-1 is a hormone your gut produces naturally, lasting only 1-2 minutes. GLP-1 receptor agonists are engineered to activate the same receptors for days instead of minutes, providing sustained appetite regulation and metabolic support.
Preserves benefits
Research suggests that low-dose semaglutide can activate longevity-relevant pathways including moderate weight loss, glycemic control, and liver health.
Reduces side effects
Side effects from semaglutide are dose-dependent. In clinical trials, dropping from 2.4 mg to 1.0 mg reduced the rate of digestive side effects by 6% (absolute reduction).
How Third Avenue works
From intake to your door in three to seven days
Step 1
Medical intake
Answer a guided set of questions covering your medical history, current medications, goals, and treatment preferences.
A few minutesStep 2
Doctor review
A U.S.-licensed, board-certified physician reviews your intake and recommends a medication, if appropriate.
Within 72 hoursStep 3
Fast shipping
Approved medications ship directly to your door in discreet packaging.
2-5 business daysStep 4
Unlimited messaging
Your doctor is available via chat any time for additional support. Video consults available.
Up to 12 months*Some states may require a synchronous audio and/or video consultation prior to a prescription being approved.
Why Third Avenue
Third Avenue
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Proactive, doctor-led care
Treatment plans designed around your goals. No wait lists.
Transparent pricing
No membership fees, no hidden costs. Pay only after a doctor prescribes.
Board-certified doctors
Specialist physicians licensed in your state, with unlimited messaging.
Curated by longevity experts
Every protocol is built by medical experts based on longevity research.
Personalized dosing
Titration matched to your goals and tolerance.
What is Semaglutide Microdose?
Low-dose semaglutide is an emerging therapeutic for patients who experience side effects at standard doses. Early research suggests it may preserve the same longevity-relevant mechanisms as higher doses, including glycemic control, liver health, inflammation, and oxidative stress.
How do you take Semaglutide Microdose?
Semaglutide Microdose is available in a weekly injectable form. Your provider will determine which medication and dose is appropriate for you. Always follow instructions from your doctor.
What are the side effects of Semaglutide Microdose?
Higher doses of semaglutide are associated with more side effects. At full dose, the most common side effects are nausea, diarrhea, vomiting, constipation, abdominal pain, headache, and fatigue. Lower doses and slower titration can reduce the frequency of these side effects.
Who shouldn't take Semaglutide Microdose?
Not recommended for people with a personal or family history of medullary thyroid cancer or MEN2. Your doctor will evaluate whether Semaglutide Microdose is appropriate for you.